Assay Detail
Functional
CHEMBL2020907
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Cytotoxicity against human A549 cells after 72 hrs by MTT assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and cytotoxic activity evaluation of dihydrocucurbitacin B and cucurbitacin B derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 5.27 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL507237 | CUCURBITACIN B | — | 1 | 7.40 |
| CHEMBL2017884 | — | — | 1 | 6.92 |
| CHEMBL2017887 | — | — | 1 | 6.92 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 6.72 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.93 |
| CHEMBL2017875 | — | — | 1 | 5.58 |
| CHEMBL2017888 | — | — | 1 | 5.16 |
| CHEMBL2017890 | — | — | 1 | 4.94 |
| CHEMBL2017882 | — | — | 1 | 4.94 |
| CHEMBL553851 | 23,24-DIHYDROCUCURBITACIN B | — | 1 | 4.92 |
| CHEMBL2016591 | — | — | 1 | 4.58 |
| CHEMBL2017883 | — | — | 1 | 4.54 |
| CHEMBL2017895 | — | — | 1 | 4.37 |
| CHEMBL2017886 | — | — | 1 | 4.26 |
| CHEMBL2017889 | — | — | 1 | 4.18 |
| CHEMBL2017873 | — | — | 1 | 4.14 |
| CHEMBL2017896 | — | — | 1 | 4.11 |
| CHEMBL2017891 | — | — | 1 | - |
| CHEMBL256519 | — | — | 1 | - |
| CHEMBL2017897 | — | — | 1 | - |
| CHEMBL2017874 | — | — | 1 | - |
| CHEMBL2017894 | — | — | 1 | - |
| CHEMBL2017893 | — | — | 1 | - |
| CHEMBL484847 | HEXANORCUCURBITACIN F | — | 1 | - |
| CHEMBL2017892 | — | — | 1 | - |
| CHEMBL2017881 | — | — | 1 | - |
| CHEMBL2017876 | — | — | 1 | - |
| CHEMBL2017877 | — | — | 1 | - |
| CHEMBL2017878 | — | — | 1 | - |
| CHEMBL2017872 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL507237 | CUCURBITACIN B | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2017884 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2017887 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL2017875 | — | IC50 | = | 2640.0 | nM | 5.58 |
| CHEMBL2017888 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL2017890 | — | IC50 | = | 11470.0 | nM | 4.94 |
| CHEMBL2017882 | — | IC50 | = | 11520.0 | nM | 4.94 |
| CHEMBL553851 | 23,24-DIHYDROCUCURBITACIN B | IC50 | = | 12090.0 | nM | 4.92 |
| CHEMBL2016591 | — | IC50 | = | 26490.0 | nM | 4.58 |
| CHEMBL2017883 | — | IC50 | = | 29090.0 | nM | 4.54 |
| CHEMBL2017895 | — | IC50 | = | 42600.0 | nM | 4.37 |
| CHEMBL2017886 | — | IC50 | = | 55190.0 | nM | 4.26 |
| CHEMBL2017889 | — | IC50 | = | 66740.0 | nM | 4.18 |
| CHEMBL2017873 | — | IC50 | = | 72520.0 | nM | 4.14 |
| CHEMBL2017896 | — | IC50 | = | 77740.0 | nM | 4.11 |
| CHEMBL2017891 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL256519 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2017897 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2017874 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2017894 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2017893 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL484847 | HEXANORCUCURBITACIN F | IC50 | > | 100000.0 | nM | - |
| CHEMBL2017892 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2017881 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2017876 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2017877 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2017878 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2017872 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2017885 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2017879 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2017880 | — | IC50 | > | 100000.0 | nM | - |