Assay Detail
Functional
CHEMBL2021256
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Cytotoxicity against human A549 cells after 72 hrs by MTS assay
14
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
In vitro growth inhibition of human cancer cells by novel honokiol analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.68 | 5.98 |
| GI | 7 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2017171 | — | — | 2 | 5.98 |
| CHEMBL2018421 | — | — | 2 | 5.97 |
| CHEMBL89700 | METHYLHONOKIOL | — | 2 | 5.91 |
| CHEMBL2018418 | — | — | 2 | 5.90 |
| CHEMBL2018419 | — | — | 2 | 5.70 |
| CHEMBL2018420 | — | — | 2 | 5.20 |
| CHEMBL16901 | HONOKIOL | — | 2 | 5.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2017171 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL2018421 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL89700 | METHYLHONOKIOL | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL2018418 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL2018419 | — | IC50 | = | 1990.0 | nM | 5.70 |
| CHEMBL2018420 | — | IC50 | = | 6280.0 | nM | 5.20 |
| CHEMBL16901 | HONOKIOL | IC50 | = | 7750.0 | nM | 5.11 |
| CHEMBL89700 | METHYLHONOKIOL | GI | - | — | - | |
| CHEMBL2017171 | — | GI | - | — | - | |
| CHEMBL2018418 | — | GI | - | — | - | |
| CHEMBL2018419 | — | GI | - | — | - | |
| CHEMBL2018420 | — | GI | - | — | - | |
| CHEMBL2018421 | — | GI | - | — | - | |
| CHEMBL16901 | HONOKIOL | GI | - | — | - |