Assay Detail
Functional
CHEMBL2024710
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Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum GHA infected in human erythrocytes after 72 hrs using malstat staining by spectrophotometry
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Drug-to-genome-to-drug, step 2: reversing selectivity in a series of antiplasmodial compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.69 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2022215 | — | — | 1 | 6.66 |
| CHEMBL2022216 | — | — | 1 | 6.60 |
| CHEMBL284745 | — | — | 1 | 6.38 |
| CHEMBL32255 | — | — | 1 | 6.30 |
| CHEMBL2022209 | — | — | 1 | 6.28 |
| CHEMBL2022223 | — | — | 1 | 6.28 |
| CHEMBL2022219 | — | — | 1 | 6.22 |
| CHEMBL2022222 | — | — | 1 | 6.21 |
| CHEMBL2021966 | — | — | 1 | 6.16 |
| CHEMBL2022213 | — | — | 1 | 6.10 |
| CHEMBL2022217 | — | — | 1 | 6.05 |
| CHEMBL286905 | — | — | 1 | 6.00 |
| CHEMBL2022214 | — | — | 1 | 5.70 |
| CHEMBL2022212 | — | — | 1 | 5.40 |
| CHEMBL2024105 | — | — | 1 | 5.30 |
| CHEMBL2021965 | — | — | 1 | 5.28 |
| CHEMBL2022218 | — | — | 1 | 5.22 |
| CHEMBL2022221 | — | — | 1 | 5.16 |
| CHEMBL2022211 | — | — | 1 | 5.16 |
| CHEMBL2022210 | — | — | 1 | 5.00 |
| CHEMBL2022220 | — | — | 1 | 4.96 |
| CHEMBL2022224 | — | — | 1 | 4.96 |
| CHEMBL2024106 | — | — | 1 | 4.96 |
| CHEMBL2021963 | — | — | 1 | 4.92 |
| CHEMBL2021964 | — | — | 1 | 4.92 |
| CHEMBL779 | TADALAFIL | 4.0 | 1 | - |
| CHEMBL2024107 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2022215 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL2022216 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL284745 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL32255 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2022209 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL2022223 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL2022219 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL2022222 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL2021966 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL2022213 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL2022217 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL286905 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2022214 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2022212 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL2024105 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL2021965 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL2022218 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL2022221 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL2022211 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL2022210 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2022220 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL2022224 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL2024106 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL2021963 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL2021964 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL779 | TADALAFIL | IC50 | > | 64000.0 | nM | - |
| CHEMBL2024107 | — | IC50 | > | 64000.0 | nM | - |