Assay Detail
Binding
CHEMBL2024776
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Inhibition of KDR using 1 mM ATP by HTRF assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Thienopyridine ureas as dual inhibitors of the VEGF and Aurora kinase families.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 8.32 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2022853 | — | — | 1 | 9.00 |
| CHEMBL2022857 | — | — | 1 | 8.70 |
| CHEMBL2023221 | — | — | 1 | 8.70 |
| CHEMBL1980297 | ILORASERTIB | 2.0 | 1 | 8.70 |
| CHEMBL2022850 | — | — | 1 | 8.70 |
| CHEMBL1969102 | — | — | 1 | 8.70 |
| CHEMBL2023225 | — | — | 1 | 8.70 |
| CHEMBL2023232 | — | — | 1 | 8.52 |
| CHEMBL1967116 | — | — | 1 | 8.52 |
| CHEMBL2023226 | — | — | 1 | 8.52 |
| CHEMBL2023227 | — | — | 1 | 8.52 |
| CHEMBL2022856 | — | — | 1 | 8.52 |
| CHEMBL1970317 | — | — | 1 | 8.52 |
| CHEMBL2022854 | — | — | 1 | 8.40 |
| CHEMBL2021941 | — | — | 1 | 8.40 |
| CHEMBL2023220 | — | — | 1 | 8.22 |
| CHEMBL2023224 | — | — | 1 | 8.22 |
| CHEMBL2023230 | — | — | 1 | 8.22 |
| CHEMBL2023231 | — | — | 1 | 8.22 |
| CHEMBL2022855 | — | — | 1 | 8.22 |
| CHEMBL1982466 | — | — | 1 | 8.22 |
| CHEMBL2023228 | — | — | 1 | 8.15 |
| CHEMBL1979883 | — | — | 1 | 8.15 |
| CHEMBL2023229 | — | — | 1 | 8.10 |
| CHEMBL2023222 | — | — | 1 | 8.10 |
| CHEMBL2023223 | — | — | 1 | 8.05 |
| CHEMBL394619 | — | — | 1 | 8.05 |
| CHEMBL231511 | — | — | 1 | 7.89 |
| CHEMBL1993941 | — | — | 1 | 7.82 |
| CHEMBL2022851 | — | — | 1 | 7.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2022853 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2022857 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2023221 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1980297 | ILORASERTIB | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2022850 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1969102 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2023225 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2023232 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1967116 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2023226 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2023227 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2022856 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1970317 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2022854 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2021941 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2023220 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2023224 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2023230 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2023231 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2022855 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1982466 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2023228 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1979883 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2023229 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2023222 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2023223 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL394619 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL231511 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1993941 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2022851 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2022852 | — | IC50 | = | 25.0 | nM | 7.60 |