Assay Detail
Binding
CHEMBL2024778
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Inhibition of human KDR phosphorylation expressed in mouse NIH3T3 cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | NIH3T3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Thienopyridine ureas as dual inhibitors of the VEGF and Aurora kinase families.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.03 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2023221 | — | — | 1 | 9.00 |
| CHEMBL2021941 | — | — | 1 | 9.00 |
| CHEMBL2023224 | — | — | 1 | 8.52 |
| CHEMBL1979883 | — | — | 1 | 8.10 |
| CHEMBL2023222 | — | — | 1 | 7.85 |
| CHEMBL1969102 | — | — | 1 | 7.85 |
| CHEMBL1967116 | — | — | 1 | 7.85 |
| CHEMBL2023220 | — | — | 1 | 7.66 |
| CHEMBL2023223 | — | — | 1 | 7.51 |
| CHEMBL394619 | — | — | 1 | 7.50 |
| CHEMBL231511 | — | — | 1 | 7.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2023221 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2021941 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2023224 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1979883 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2023222 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1969102 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1967116 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2023220 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL2023223 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL394619 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL231511 | — | IC50 | = | 33.0 | nM | 7.48 |