Assay Detail
Binding
CHEMBL2024801
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Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate after 15 mins by Ellman's method
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.22 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95 | TACRINE | 4.0 | 1 | 8.28 |
| CHEMBL2022929 | — | — | 1 | 5.18 |
| CHEMBL2022928 | — | — | 1 | 5.16 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 5.13 |
| CHEMBL2022934 | — | — | 1 | 5.00 |
| CHEMBL2022923 | — | — | 1 | 4.96 |
| CHEMBL2022926 | — | — | 1 | 4.85 |
| CHEMBL2022927 | — | — | 1 | 4.66 |
| CHEMBL2022933 | — | — | 1 | 4.57 |
| CHEMBL2021938 | — | — | 1 | 4.37 |
| CHEMBL2022924 | — | — | 1 | - |
| CHEMBL2022925 | — | — | 1 | - |
| CHEMBL2022930 | — | — | 1 | - |
| CHEMBL2022931 | — | — | 1 | - |
| CHEMBL2022932 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95 | TACRINE | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL2022929 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL2022928 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL2022934 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2022923 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL2022926 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL2022927 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL2022933 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL2021938 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL2022924 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2022925 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2022930 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2022931 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2022932 | — | IC50 | > | 100000.0 | nM | - |