Assay Detail
Binding
CHEMBL2024802
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of electric eel AChE using acetylthiocholine iodide as substrate after 15 mins by Ellman's method
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.00 | 8.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 8.17 |
| CHEMBL2022933 | — | — | 1 | 7.60 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.57 |
| CHEMBL2022932 | — | — | 1 | 7.54 |
| CHEMBL2022934 | — | — | 1 | 7.18 |
| CHEMBL2022931 | — | — | 1 | 6.27 |
| CHEMBL2022930 | — | — | 1 | 5.85 |
| CHEMBL2022929 | — | — | 1 | 5.82 |
| CHEMBL2022923 | — | — | 1 | - |
| CHEMBL2022924 | — | — | 1 | - |
| CHEMBL2022925 | — | — | 1 | - |
| CHEMBL2022926 | — | — | 1 | - |
| CHEMBL2021938 | — | — | 1 | - |
| CHEMBL2022927 | — | — | 1 | - |
| CHEMBL2022928 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL2022933 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL95 | TACRINE | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL2022932 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL2022934 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL2022931 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL2022930 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL2022929 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2022923 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2022924 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2022925 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2022926 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2021938 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2022927 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2022928 | — | IC50 | > | 100000.0 | nM | - |