Assay Detail
Functional
CHEMBL2024804
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human alpha7 nAChR expressed in GH4C1 cells by FLIPR assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | GH4-C1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL2492) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of a series of 1,3,4-oxadiazol-2-amines as potent alpha-7 agonists with efficacy in the novel object recognition model of cognition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 27 | 6.46 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2022495 | — | — | 1 | 7.30 |
| CHEMBL2022496 | — | — | 1 | 7.20 |
| CHEMBL2023927 | — | — | 1 | 7.00 |
| CHEMBL2022939 | — | — | 1 | 7.00 |
| CHEMBL2023930 | — | — | 1 | 6.90 |
| CHEMBL2023928 | — | — | 1 | 6.90 |
| CHEMBL2023919 | — | — | 1 | 6.80 |
| CHEMBL2022499 | — | — | 1 | 6.80 |
| CHEMBL2022938 | — | — | 1 | 6.70 |
| CHEMBL2022935 | — | — | 1 | 6.70 |
| CHEMBL2023929 | — | — | 1 | 6.70 |
| CHEMBL2023924 | — | — | 1 | 6.70 |
| CHEMBL2023917 | — | — | 1 | 6.60 |
| CHEMBL2021948 | — | — | 1 | 6.60 |
| CHEMBL2022497 | — | — | 1 | 6.50 |
| CHEMBL2023916 | — | — | 1 | 6.50 |
| CHEMBL2022940 | — | — | 1 | 6.40 |
| CHEMBL2023925 | — | — | 1 | 6.40 |
| CHEMBL2023920 | — | — | 1 | 6.30 |
| CHEMBL2023926 | — | — | 1 | 6.30 |
| CHEMBL2022941 | — | — | 1 | 6.20 |
| CHEMBL2023918 | — | — | 1 | 6.00 |
| CHEMBL2023921 | — | — | 1 | 5.90 |
| CHEMBL2023923 | — | — | 1 | 5.70 |
| CHEMBL2023922 | — | — | 1 | 5.50 |
| CHEMBL2022936 | — | — | 1 | 5.40 |
| CHEMBL2022937 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2022495 | — | EC50 | = | 50.12 | nM | 7.30 |
| CHEMBL2022496 | — | EC50 | = | 63.1 | nM | 7.20 |
| CHEMBL2023927 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2022939 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2023930 | — | EC50 | = | 125.89 | nM | 6.90 |
| CHEMBL2023928 | — | EC50 | = | 125.89 | nM | 6.90 |
| CHEMBL2023919 | — | EC50 | = | 158.49 | nM | 6.80 |
| CHEMBL2022499 | — | EC50 | = | 158.49 | nM | 6.80 |
| CHEMBL2022938 | — | EC50 | = | 199.53 | nM | 6.70 |
| CHEMBL2022935 | — | EC50 | = | 199.53 | nM | 6.70 |
| CHEMBL2023929 | — | EC50 | = | 199.53 | nM | 6.70 |
| CHEMBL2023924 | — | EC50 | = | 199.53 | nM | 6.70 |
| CHEMBL2023917 | — | EC50 | = | 251.19 | nM | 6.60 |
| CHEMBL2021948 | — | EC50 | = | 251.19 | nM | 6.60 |
| CHEMBL2022497 | — | EC50 | = | 316.23 | nM | 6.50 |
| CHEMBL2023916 | — | EC50 | = | 316.23 | nM | 6.50 |
| CHEMBL2022940 | — | EC50 | = | 398.11 | nM | 6.40 |
| CHEMBL2023925 | — | EC50 | = | 398.11 | nM | 6.40 |
| CHEMBL2023920 | — | EC50 | = | 501.19 | nM | 6.30 |
| CHEMBL2023926 | — | EC50 | = | 501.19 | nM | 6.30 |
| CHEMBL2022941 | — | EC50 | = | 630.96 | nM | 6.20 |
| CHEMBL2023918 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2023921 | — | EC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL2023923 | — | EC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL2023922 | — | EC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL2022936 | — | EC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL2022937 | — | EC50 | = | 5011.87 | nM | 5.30 |