Assay Detail
Binding
CHEMBL2024805
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]Dofetilide from human ERG expressed in CHO-K1 cells by scintillation proximity assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of a series of 1,3,4-oxadiazol-2-amines as potent alpha-7 agonists with efficacy in the novel object recognition model of cognition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.00 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2023925 | — | — | 1 | 5.40 |
| CHEMBL2023924 | — | — | 1 | 5.40 |
| CHEMBL2023930 | — | — | 1 | 5.40 |
| CHEMBL2023929 | — | — | 1 | 5.30 |
| CHEMBL2022495 | — | — | 1 | 5.30 |
| CHEMBL2022938 | — | — | 1 | 5.20 |
| CHEMBL2023921 | — | — | 1 | 5.20 |
| CHEMBL2022499 | — | — | 1 | 5.10 |
| CHEMBL2023917 | — | — | 1 | 5.10 |
| CHEMBL2023916 | — | — | 1 | 5.10 |
| CHEMBL2022941 | — | — | 1 | 5.10 |
| CHEMBL2022496 | — | — | 1 | 5.10 |
| CHEMBL2021948 | — | — | 1 | 5.00 |
| CHEMBL2023928 | — | — | 1 | 5.00 |
| CHEMBL2022940 | — | — | 1 | 4.90 |
| CHEMBL2023927 | — | — | 1 | 4.90 |
| CHEMBL2022935 | — | — | 1 | 4.90 |
| CHEMBL2023923 | — | — | 1 | 4.80 |
| CHEMBL2022939 | — | — | 1 | 4.80 |
| CHEMBL2023926 | — | — | 1 | 4.80 |
| CHEMBL2023919 | — | — | 1 | 4.70 |
| CHEMBL2023920 | — | — | 1 | 4.70 |
| CHEMBL2023918 | — | — | 1 | 4.60 |
| CHEMBL2023922 | — | — | 1 | 4.60 |
| CHEMBL2022497 | — | — | 1 | 4.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2023925 | — | IC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL2023924 | — | IC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL2023930 | — | IC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL2023929 | — | IC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL2022495 | — | IC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL2022938 | — | IC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL2023921 | — | IC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL2022499 | — | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL2023917 | — | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL2023916 | — | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL2022941 | — | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL2022496 | — | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL2021948 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2023928 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2022940 | — | IC50 | = | 12589.25 | nM | 4.90 |
| CHEMBL2023927 | — | IC50 | = | 12589.25 | nM | 4.90 |
| CHEMBL2022935 | — | IC50 | = | 12589.25 | nM | 4.90 |
| CHEMBL2023923 | — | IC50 | = | 15848.93 | nM | 4.80 |
| CHEMBL2022939 | — | IC50 | = | 15848.93 | nM | 4.80 |
| CHEMBL2023926 | — | IC50 | = | 15848.93 | nM | 4.80 |
| CHEMBL2023919 | — | IC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL2023920 | — | IC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL2023918 | — | IC50 | = | 25118.86 | nM | 4.60 |
| CHEMBL2023922 | — | IC50 | = | 25118.86 | nM | 4.60 |
| CHEMBL2022497 | — | IC50 | = | 31622.78 | nM | 4.50 |