Assay Detail

CHEMBL2024938

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Binding affinity to recombinant bovine PKAc by fluorescence anisotropy assay

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Bos taurus
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Conjugates of 5-isoquinolinesulfonylamides and oligo-D-arginine possess high affinity and selectivity towards Rho kinase (ROCK).

Lavogina D, Kalind K, Bredihhina J, Hurt M, Vaasa A, Kasari M, Enkvist E, Raidaru G, Uri A.
Bioorg Med Chem Lett (2012) 22 : 3425 -3430
PubMed 22521647 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Kd	2	9.28	9.28

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL2023845	—	—	1	9.28
CHEMBL2023841	—	—	1	9.28

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL2023845	—	Kd	=	0.52	nM	9.28
CHEMBL2023841	—	Kd	=	0.52	nM	9.28