Assay Detail
Binding
CHEMBL2024945
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of fluorescent-ARC-583/ARC-1042/ARC-1059 from His6-tagged recombinant human AKT3 S472D mutant by fluorescence anisotropy assay
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
RAC-gamma serine/threonine-protein kinase (CHEMBL4816) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Conjugates of 5-isoquinolinesulfonylamides and oligo-D-arginine possess high affinity and selectivity towards Rho kinase (ROCK).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 6.21 | 7.26 |
| IC50 | 2 | 6.09 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2023714 | — | — | 2 | 7.26 |
| CHEMBL2023842 | — | — | 2 | 5.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2023714 | — | Kd | = | 55.0 | nM | 7.26 |
| CHEMBL2023714 | — | IC50 | = | 72.44 | nM | 7.14 |
| CHEMBL2023842 | — | Kd | = | 7100.0 | nM | 5.15 |
| CHEMBL2023842 | — | IC50 | = | 9120.11 | nM | 5.04 |