Assay Detail
Binding
CHEMBL2025082
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant COX2
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Crystal structures of AKR1C3 containing an N-(aryl)amino-benzoate inhibitor and a bifunctional AKR1C3 inhibitor and androgen receptor antagonist. Therapeutic leads for castrate resistant prostate cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.92 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23588 | FLUFENAMIC ACID | 2.0 | 1 | 7.70 |
| CHEMBL1682200 | — | — | 1 | 6.13 |
| CHEMBL1682202 | — | — | 1 | - |
| CHEMBL2023820 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23588 | FLUFENAMIC ACID | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1682200 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL1682202 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2023820 | — | IC50 | > | 100000.0 | nM | - |