Assay Detail
Binding
CHEMBL2025280
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Inhibition of HDAC6 in human HeLa cell nuclear extract using Fluor de Lys as substrate after 15 mins by fluorometric analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dual targeting of histone deacetylase and topoisomerase II with novel bifunctional inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.41 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2023530 | — | — | 1 | 7.72 |
| CHEMBL2023529 | — | — | 1 | 7.70 |
| CHEMBL2023526 | — | — | 1 | 7.70 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.57 |
| CHEMBL2023528 | — | — | 1 | 7.52 |
| CHEMBL2023527 | — | — | 1 | 6.26 |
| CHEMBL178 | DAUNORUBICIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2023530 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2023529 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2023526 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL2023528 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2023527 | — | IC50 | = | 555.0 | nM | 6.26 |
| CHEMBL178 | DAUNORUBICIN | IC50 | - | — | - |