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Assay Detail

CHEMBL2025554

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of COX2 by fluorescence assay
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Prostaglandin G/H synthase 2 (CHEMBL230)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and biological activity of 2-aminothiazoles as novel inhibitors of PGE2 production in cells.
Smith B, Chang HH, Medda F, Gokhale V, Dietrich J, Davis A, Meuillet EJ, Hulme C.
Bioorg Med Chem Lett (2012) 22 : 3567 -3570
PubMed 22516282 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 37 6.15 7.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL118 CELECOXIB 4.0 1 7.52
CHEMBL1894768 1 6.39
CHEMBL2023858 1 6.09
CHEMBL2023847 1 6.08
CHEMBL2023862 1 6.04
CHEMBL2023861 1 6.04
CHEMBL2023859 1 6.04
CHEMBL2023860 1 6.03
CHEMBL2023850 1 5.97
CHEMBL2023857 1 5.92
CHEMBL1622194 1 5.86
CHEMBL2023848 1 5.86
CHEMBL2023851 1 -
CHEMBL2023846 1 -
CHEMBL2023950 1 -
CHEMBL68504 1 -
CHEMBL2023849 1 -
CHEMBL2023949 1 -
CHEMBL2023946 1 -
CHEMBL2023945 1 -
CHEMBL2023947 1 -
CHEMBL2023864 1 -
CHEMBL2023863 1 -
CHEMBL1901087 1 -
CHEMBL1896872 1 -
CHEMBL1235108 1 -
CHEMBL1080721 1 -
CHEMBL2023856 1 -
CHEMBL2023855 1 -
CHEMBL2023854 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL118 CELECOXIB IC50 = 30.0 nM 7.52
CHEMBL1894768 IC50 = 410.0 nM 6.39
CHEMBL2023858 IC50 = 810.0 nM 6.09
CHEMBL2023847 IC50 = 840.0 nM 6.08
CHEMBL2023862 IC50 = 910.0 nM 6.04
CHEMBL2023861 IC50 = 920.0 nM 6.04
CHEMBL2023859 IC50 = 910.0 nM 6.04
CHEMBL2023860 IC50 = 930.0 nM 6.03
CHEMBL2023850 IC50 = 1080.0 nM 5.97
CHEMBL2023857 IC50 = 1200.0 nM 5.92
CHEMBL1622194 IC50 = 1370.0 nM 5.86
CHEMBL2023848 IC50 = 1390.0 nM 5.86
CHEMBL2023849 IC50 - -
CHEMBL68504 IC50 - -
CHEMBL2023950 IC50 > 5000.0 nM -
CHEMBL2023846 IC50 > 10000.0 nM -
CHEMBL2023851 IC50 > 5000.0 nM -
CHEMBL2023852 IC50 > 5000.0 nM -
CHEMBL2023853 IC50 > 5000.0 nM -
CHEMBL1907465 IC50 > 5000.0 nM -
CHEMBL1907447 IC50 > 5000.0 nM -
CHEMBL1903990 IC50 > 5000.0 nM -
CHEMBL1902481 IC50 > 5000.0 nM -
CHEMBL2023948 IC50 > 5000.0 nM -
CHEMBL2023949 IC50 > 5000.0 nM -
CHEMBL2023946 IC50 - -
CHEMBL2023945 IC50 - -
CHEMBL2023947 IC50 - -
CHEMBL2023864 IC50 - -
CHEMBL2023863 IC50 - -
CHEMBL1901087 IC50 - -
CHEMBL1896872 IC50 - -
CHEMBL1235108 IC50 - -
CHEMBL1080721 IC50 - -
CHEMBL2023856 IC50 - -
CHEMBL2023855 IC50 - -
CHEMBL2023854 IC50 - -