Assay Detail
Functional
CHEMBL2025555
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IL-1beta-induced PGE2 production in human HCA-7 cells after 72 hrs by EIA
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCA-7 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of 2-aminothiazoles as novel inhibitors of PGE2 production in cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 37 | 6.81 | 8.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 8.94 |
| CHEMBL2023950 | — | — | 1 | 7.05 |
| CHEMBL2023853 | — | — | 1 | 6.92 |
| CHEMBL1907465 | — | — | 1 | 6.75 |
| CHEMBL1903990 | — | — | 1 | 6.62 |
| CHEMBL2023846 | — | — | 1 | 6.55 |
| CHEMBL2023851 | — | — | 1 | 6.54 |
| CHEMBL1907447 | — | — | 1 | 6.54 |
| CHEMBL2023948 | — | — | 1 | 6.50 |
| CHEMBL2023852 | — | — | 1 | 6.48 |
| CHEMBL2023949 | — | — | 1 | 6.43 |
| CHEMBL1902481 | — | — | 1 | 6.41 |
| CHEMBL2023855 | — | — | 1 | - |
| CHEMBL2023856 | — | — | 1 | - |
| CHEMBL2023857 | — | — | 1 | - |
| CHEMBL1622194 | — | — | 1 | - |
| CHEMBL2023858 | — | — | 1 | - |
| CHEMBL2023859 | — | — | 1 | - |
| CHEMBL2023860 | — | — | 1 | - |
| CHEMBL2023861 | — | — | 1 | - |
| CHEMBL2023862 | — | — | 1 | - |
| CHEMBL1896872 | — | — | 1 | - |
| CHEMBL1901087 | — | — | 1 | - |
| CHEMBL2023863 | — | — | 1 | - |
| CHEMBL2023864 | — | — | 1 | - |
| CHEMBL1235108 | — | — | 1 | - |
| CHEMBL2023945 | — | — | 1 | - |
| CHEMBL2023946 | — | — | 1 | - |
| CHEMBL2023947 | — | — | 1 | - |
| CHEMBL1894768 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | EC50 | = | 1.15 | nM | 8.94 |
| CHEMBL2023950 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL2023853 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1907465 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1903990 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL2023846 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL2023851 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL1907447 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL2023948 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL2023852 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL2023949 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL1902481 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL2023858 | — | EC50 | - | — | - | |
| CHEMBL1622194 | — | EC50 | - | — | - | |
| CHEMBL2023857 | — | EC50 | - | — | - | |
| CHEMBL2023856 | — | EC50 | - | — | - | |
| CHEMBL2023855 | — | EC50 | - | — | - | |
| CHEMBL2023854 | — | EC50 | - | — | - | |
| CHEMBL2023850 | — | EC50 | - | — | - | |
| CHEMBL1080721 | — | EC50 | - | — | - | |
| CHEMBL2023849 | — | EC50 | - | — | - | |
| CHEMBL68504 | — | EC50 | - | — | - | |
| CHEMBL2023848 | — | EC50 | - | — | - | |
| CHEMBL2023847 | — | EC50 | - | — | - | |
| CHEMBL2023859 | — | EC50 | - | — | - | |
| CHEMBL2023860 | — | EC50 | - | — | - | |
| CHEMBL2023861 | — | EC50 | - | — | - | |
| CHEMBL2023862 | — | EC50 | - | — | - | |
| CHEMBL1896872 | — | EC50 | - | — | - | |
| CHEMBL1901087 | — | EC50 | - | — | - | |
| CHEMBL2023863 | — | EC50 | - | — | - | |
| CHEMBL2023864 | — | EC50 | - | — | - | |
| CHEMBL1235108 | — | EC50 | - | — | - | |
| CHEMBL2023945 | — | EC50 | - | — | - | |
| CHEMBL2023946 | — | EC50 | - | — | - | |
| CHEMBL2023947 | — | EC50 | - | — | - | |
| CHEMBL1894768 | — | EC50 | - | — | - |