Assay Detail
Functional
CHEMBL2025605
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplasmodial activity chloroquine-sensitive Plasmodium falciparum 3D7 infected in human A+ erythrocytes assessed as inhibition of [3H]-hypoxanthine incorporation after 24 hrs by scintillation counting
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure-activity relationship and mode of action studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.61 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 8.85 |
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | 8.28 |
| CHEMBL2023610 | — | — | 1 | 7.74 |
| CHEMBL2023440 | — | — | 1 | 7.66 |
| CHEMBL2023605 | — | — | 1 | 7.38 |
| CHEMBL2023604 | — | — | 1 | 7.20 |
| CHEMBL2023608 | — | — | 1 | 6.76 |
| CHEMBL2023442 | — | — | 1 | 6.69 |
| CHEMBL2023441 | — | — | 1 | 6.61 |
| CHEMBL2023444 | — | — | 1 | 6.60 |
| CHEMBL2023446 | — | — | 1 | 6.58 |
| CHEMBL2023450 | — | — | 1 | 6.54 |
| CHEMBL2023611 | — | — | 1 | 6.30 |
| CHEMBL2023606 | — | — | 1 | 6.22 |
| CHEMBL2023448 | — | — | 1 | 6.19 |
| CHEMBL2023607 | — | — | 1 | 6.16 |
| CHEMBL2023443 | — | — | 1 | 5.95 |
| CHEMBL2023445 | — | — | 1 | 5.75 |
| CHEMBL2023609 | — | — | 1 | 5.71 |
| CHEMBL2023447 | — | — | 1 | 4.83 |
| CHEMBL2023449 | — | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL361497 | ARTESUNATE | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL2023610 | — | IC50 | = | 18.2 | nM | 7.74 |
| CHEMBL2023440 | — | IC50 | = | 21.7 | nM | 7.66 |
| CHEMBL2023605 | — | IC50 | = | 42.1 | nM | 7.38 |
| CHEMBL2023604 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL2023608 | — | IC50 | = | 172.9 | nM | 6.76 |
| CHEMBL2023442 | — | IC50 | = | 202.3 | nM | 6.69 |
| CHEMBL2023441 | — | IC50 | = | 247.5 | nM | 6.61 |
| CHEMBL2023444 | — | IC50 | = | 252.2 | nM | 6.60 |
| CHEMBL2023446 | — | IC50 | = | 264.8 | nM | 6.58 |
| CHEMBL2023450 | — | IC50 | = | 286.7 | nM | 6.54 |
| CHEMBL2023611 | — | IC50 | = | 499.9 | nM | 6.30 |
| CHEMBL2023606 | — | IC50 | = | 598.7 | nM | 6.22 |
| CHEMBL2023448 | — | IC50 | = | 644.4 | nM | 6.19 |
| CHEMBL2023607 | — | IC50 | = | 697.2 | nM | 6.16 |
| CHEMBL2023443 | — | IC50 | = | 1134.9 | nM | 5.95 |
| CHEMBL2023445 | — | IC50 | = | 1776.8 | nM | 5.75 |
| CHEMBL2023609 | — | IC50 | = | 1955.1 | nM | 5.71 |
| CHEMBL2023447 | — | IC50 | = | 14828.3 | nM | 4.83 |
| CHEMBL2023449 | — | IC50 | = | 15888.5 | nM | 4.80 |