Assay Detail
Functional
CHEMBL2025708
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Antiviral activity against Hepatitis C virus genotype 1a assessed as inhibition of viral replication by replicon assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Hepatitis C RNA-dependent RNA polymerase inhibitors: a review of structure-activity and resistance relationships; different scaffolds and mutations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 7.42 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1092581 | NESBUVIR | 2.0 | 1 | 8.30 |
| CHEMBL2024212 | GSK-625433 | 1.0 | 1 | 6.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1092581 | NESBUVIR | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2024212 | GSK-625433 | EC50 | = | 290.0 | nM | 6.54 |