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Assay Detail

CHEMBL2025720

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of ovine COX2 by enzyme immuno assay
ChEMBL ↗
45
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Ovis aries
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Prostaglandin G/H synthase 2 (CHEMBL4102) ↗
Type SINGLE PROTEIN
Organism Ovis aries

Publication

Synthesis, biological evaluation and molecular modeling study of pyrazole and pyrazoline derivatives as selective COX-2 inhibitors and anti-inflammatory agents. Part 2.
El-Sayed MA, Abdel-Aziz NI, Abdel-Aziz AA, El-Azab AS, ElTahir KE.
Bioorg Med Chem (2012) 20 : 3306 -3316
PubMed 22516672 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 45 5.71 6.58

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2024229 — — 2 6.58
CHEMBL118 CELECOXIB 4.0 1 6.55
CHEMBL2024222 — — 2 6.54
CHEMBL2024228 — — 2 6.39
CHEMBL2024223 — — 2 6.37
CHEMBL1780080 — — 1 6.35
CHEMBL1780077 — — 1 6.35
CHEMBL2024220 — — 2 6.32
CHEMBL2024216 — — 2 6.30
CHEMBL1780083 — — 1 6.26
CHEMBL2024217 — — 2 6.18
CHEMBL2024214 — — 2 5.92
CHEMBL2024221 — — 2 5.68
CHEMBL1034 DICLOFENAC SODIUM 4.0 1 5.51
CHEMBL2024226 — — 2 5.50
CHEMBL2024215 — — 2 5.48
CHEMBL2024218 — — 2 4.40
CHEMBL2024219 — — 2 4.35
CHEMBL2021951 — — 2 4.34
CHEMBL2024224 — — 2 4.32
CHEMBL2024227 — — 2 4.31
CHEMBL2024225 — — 2 -
CHEMBL2024230 — — 2 -
CHEMBL2024452 — — 2 -
CHEMBL2024453 — — 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2024229 — IC50 = 260.0 nM 6.58
CHEMBL118 CELECOXIB IC50 = 280.0 nM 6.55
CHEMBL2024222 — IC50 = 290.0 nM 6.54
CHEMBL2024228 — IC50 = 410.0 nM 6.39
CHEMBL2024223 — IC50 = 430.0 nM 6.37
CHEMBL1780080 — IC50 = 450.0 nM 6.35
CHEMBL1780077 — IC50 = 450.0 nM 6.35
CHEMBL2024220 — IC50 = 480.0 nM 6.32
CHEMBL2024216 — IC50 = 500.0 nM 6.30
CHEMBL1780083 — IC50 = 550.0 nM 6.26
CHEMBL2024217 — IC50 = 660.0 nM 6.18
CHEMBL2024214 — IC50 = 1200.0 nM 5.92
CHEMBL2024221 — IC50 = 2100.0 nM 5.68
CHEMBL1034 DICLOFENAC SODIUM IC50 = 3100.0 nM 5.51
CHEMBL2024226 — IC50 = 3200.0 nM 5.50
CHEMBL2024215 — IC50 = 3300.0 nM 5.48
CHEMBL2024218 — IC50 = 40200.0 nM 4.40
CHEMBL2024219 — IC50 = 44400.0 nM 4.35
CHEMBL2021951 — IC50 = 46000.0 nM 4.34
CHEMBL2024224 — IC50 = 48000.0 nM 4.32
CHEMBL2024227 — IC50 = 49000.0 nM 4.31
CHEMBL2024452 — IC50 > 50000.0 nM -
CHEMBL2024230 — IC50 > 50000.0 nM -
CHEMBL2021951 — IC50 = 21877616.24 nM -
CHEMBL2024214 — IC50 = 831763771.1 nM -
CHEMBL2024215 — IC50 = 301995172.04 nM -
CHEMBL2024216 — IC50 = 501187233.63 nM -
CHEMBL2024217 — IC50 = 660693448.01 nM -
CHEMBL2024218 — IC50 = 25118864.32 nM -
CHEMBL2024219 — IC50 = 22387211.39 nM -
CHEMBL2024220 — IC50 = 478630092.32 nM -
CHEMBL2024221 — IC50 = 478630092.32 nM -
CHEMBL2024222 — IC50 = 288403150.31 nM -
CHEMBL2024453 — IC50 > 50000.0 nM -
CHEMBL2024224 — IC50 = 20892961.31 nM -
CHEMBL2024225 — IC50 = 19952623.15 nM -
CHEMBL2024226 — IC50 = 309029543.25 nM -
CHEMBL2024227 — IC50 = 20417379.45 nM -
CHEMBL2024228 — IC50 = 407380277.8 nM -
CHEMBL2024229 — IC50 = 257039578.28 nM -
CHEMBL2024230 — IC50 = 19952623.15 nM -
CHEMBL2024452 — IC50 = 19952623.15 nM -
CHEMBL2024453 — IC50 = 19952623.15 nM -
CHEMBL2024225 — IC50 > 50000.0 nM -
CHEMBL2024223 — IC50 = 426579518.8 nM -