Assay Detail
Binding
CHEMBL2025843
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Displacement of radioligand from the STAT1 after 15 mins by fluorescent polarization assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Signal transducer and activator of transcription 1-alpha/beta (CHEMBL6101) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 4.97 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2023985 | — | — | 1 | 5.50 |
| CHEMBL1829870 | — | — | 1 | 5.06 |
| CHEMBL2023986 | — | — | 1 | 5.02 |
| CHEMBL1829862 | — | — | 1 | 5.01 |
| CHEMBL1829874 | — | — | 1 | 4.66 |
| CHEMBL2023988 | — | — | 1 | 4.56 |
| CHEMBL1829786 | — | — | 1 | - |
| CHEMBL2023987 | — | — | 1 | - |
| CHEMBL2023989 | — | — | 1 | - |
| CHEMBL2024086 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2023985 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL1829870 | — | Ki | = | 8800.0 | nM | 5.06 |
| CHEMBL2023986 | — | Ki | = | 9500.0 | nM | 5.02 |
| CHEMBL1829862 | — | Ki | = | 9700.0 | nM | 5.01 |
| CHEMBL1829874 | — | Ki | = | 22000.0 | nM | 4.66 |
| CHEMBL2023988 | — | Ki | = | 27800.0 | nM | 4.56 |
| CHEMBL1829786 | — | Ki | > | 25000.0 | nM | - |
| CHEMBL2023987 | — | Ki | > | 25000.0 | nM | - |
| CHEMBL2023989 | — | Ki | > | 25000.0 | nM | - |
| CHEMBL2024086 | — | Ki | > | 25000.0 | nM | - |