Assay Detail
Functional
CHEMBL2025848
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Cytotoxicity against human K562 cells expressing STAT5 after 48 hrs by alamar blue fluorescent staining
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.30 | 4.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2023985 | — | — | 1 | 4.62 |
| CHEMBL1829862 | — | — | 1 | 4.38 |
| CHEMBL2024086 | — | — | 1 | 4.11 |
| CHEMBL1829870 | — | — | 1 | 4.10 |
| CHEMBL2023989 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2023985 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL1829862 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL2024086 | — | IC50 | = | 77000.0 | nM | 4.11 |
| CHEMBL1829870 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL2023989 | — | IC50 | > | 80000.0 | nM | - |