Assay Detail
Binding
CHEMBL2025880
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Inhibition of electric eel AChE using acetylcholine as substrate by Ellman's method
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibition of cholinesterase activity and amyloid aggregation by berberine-phenyl-benzoheterocyclic and tacrine-phenyl-benzoheterocyclic hybrids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.31 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2022043 | — | — | 1 | 7.77 |
| CHEMBL2022045 | — | — | 1 | 7.40 |
| CHEMBL2022049 | — | — | 1 | 7.24 |
| CHEMBL2022046 | — | — | 1 | 7.03 |
| CHEMBL2022044 | — | — | 1 | 6.98 |
| CHEMBL2022050 | — | — | 1 | 6.70 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.51 |
| CHEMBL295124 | BERBERINE | 4.0 | 1 | 6.43 |
| CHEMBL2022047 | — | — | 1 | 6.32 |
| CHEMBL2024056 | — | — | 1 | 6.11 |
| CHEMBL2022048 | — | — | 1 | 6.02 |
| CHEMBL2022041 | — | — | 1 | 6.01 |
| CHEMBL2024055 | — | — | 1 | 5.97 |
| CHEMBL2024058 | — | — | 1 | 5.83 |
| CHEMBL2024057 | — | — | 1 | 5.79 |
| CHEMBL2024054 | — | — | 1 | 5.72 |
| CHEMBL2022042 | — | — | 1 | 5.71 |
| CHEMBL2022040 | — | — | 1 | 5.67 |
| CHEMBL2024059 | — | — | 1 | 5.48 |
| CHEMBL2024053 | — | — | 1 | 5.45 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2022043 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2022045 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2022049 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL2022046 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL2022044 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL2022050 | — | IC50 | = | 201.0 | nM | 6.70 |
| CHEMBL95 | TACRINE | IC50 | = | 311.0 | nM | 6.51 |
| CHEMBL295124 | BERBERINE | IC50 | = | 374.0 | nM | 6.43 |
| CHEMBL2022047 | — | IC50 | = | 475.0 | nM | 6.32 |
| CHEMBL2024056 | — | IC50 | = | 774.0 | nM | 6.11 |
| CHEMBL2022048 | — | IC50 | = | 947.0 | nM | 6.02 |
| CHEMBL2022041 | — | IC50 | = | 976.0 | nM | 6.01 |
| CHEMBL2024055 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL2024058 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL2024057 | — | IC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL2024054 | — | IC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL2022042 | — | IC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL2022040 | — | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL2024059 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL2024053 | — | IC50 | = | 3590.0 | nM | 5.45 |
| CHEMBL140 | CURCUMIN | IC50 | - | — | - |