Assay Detail
Binding
CHEMBL2025883
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Inhibition of amyloid beta (1 to 42) self aggregation after 48 hrs by thioflavin T fluorescence assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Inhibition of cholinesterase activity and amyloid aggregation by berberine-phenyl-benzoheterocyclic and tacrine-phenyl-benzoheterocyclic hybrids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.25 | 5.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2024059 | — | — | 1 | 5.44 |
| CHEMBL2022040 | — | — | 1 | 5.43 |
| CHEMBL2024055 | — | — | 1 | 5.39 |
| CHEMBL2024056 | — | — | 1 | 5.33 |
| CHEMBL2024053 | — | — | 1 | 5.24 |
| CHEMBL2024057 | — | — | 1 | 5.19 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 4.73 |
| CHEMBL95 | TACRINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2024059 | — | IC50 | = | 3610.0 | nM | 5.44 |
| CHEMBL2022040 | — | IC50 | = | 3750.0 | nM | 5.43 |
| CHEMBL2024055 | — | IC50 | = | 4030.0 | nM | 5.39 |
| CHEMBL2024056 | — | IC50 | = | 4690.0 | nM | 5.33 |
| CHEMBL2024053 | — | IC50 | = | 5780.0 | nM | 5.24 |
| CHEMBL2024057 | — | IC50 | = | 6450.0 | nM | 5.19 |
| CHEMBL140 | CURCUMIN | IC50 | = | 18700.0 | nM | 4.73 |
| CHEMBL95 | TACRINE | IC50 | - | — | - |