Assay Detail
Binding
CHEMBL2026010
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human DPP4 after 10 mins
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel pyrrolopyrimidine analogues as potent dipeptidyl peptidase IV inhibitors based on pharmacokinetic property-driven optimization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.48 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2023067 | — | — | 1 | 8.85 |
| CHEMBL2023066 | — | — | 1 | 8.63 |
| CHEMBL2022467 | — | — | 1 | 8.58 |
| CHEMBL376359 | ALOGLIPTIN | 4.0 | 1 | 8.47 |
| CHEMBL2022464 | — | — | 1 | 7.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2023067 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL2023066 | — | IC50 | = | 2.34 | nM | 8.63 |
| CHEMBL2022467 | — | IC50 | = | 2.64 | nM | 8.58 |
| CHEMBL376359 | ALOGLIPTIN | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL2022464 | — | IC50 | = | 13.78 | nM | 7.86 |