Assay Detail
Functional
CHEMBL2026087
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Cytomegalovirus AD-169 infected in HEL cells assessed as inhibition of virus plaque formation after 4 days
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human betaherpesvirus 5 |
| Cell Type | HEL |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure-activity relationship and mode of action studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 5.67 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | 6.43 |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 5.78 |
| CHEMBL2023442 | — | — | 1 | 5.70 |
| CHEMBL2023441 | — | — | 1 | 5.40 |
| CHEMBL2023604 | — | — | 1 | 5.05 |
| CHEMBL2023440 | — | — | 1 | - |
| CHEMBL2023605 | — | — | 1 | - |
| CHEMBL2023606 | — | — | 1 | - |
| CHEMBL2023608 | — | — | 1 | - |
| CHEMBL2023610 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5314375 | CIDOFOVIR | EC50 | = | 369.0 | nM | 6.43 |
| CHEMBL182 | GANCICLOVIR | EC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL2023442 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2023441 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL2023604 | — | EC50 | = | 8940.0 | nM | 5.05 |
| CHEMBL2023440 | — | EC50 | > | 4000.0 | nM | - |
| CHEMBL2023605 | — | EC50 | > | 4000.0 | nM | - |
| CHEMBL2023606 | — | EC50 | > | 4000.0 | nM | - |
| CHEMBL2023608 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL2023610 | — | EC50 | > | 4000.0 | nM | - |