Assay Detail
Binding
CHEMBL2026264
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 membranes after 60 mins by liquid scintillation counting
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
New pyridobenzoxazepine derivatives derived from 5-(4-methylpiperazin-1-yl)-8-chloro-pyrido[2,3-b][1,5]benzoxazepine (JL13): chemical synthesis and pharmacological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.46 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2022280 | — | — | 1 | 6.75 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.73 |
| CHEMBL2022272 | — | — | 1 | 6.43 |
| CHEMBL2022273 | — | — | 1 | 6.38 |
| CHEMBL2022275 | — | — | 1 | 6.34 |
| CHEMBL2022269 | — | — | 1 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2022280 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL42 | CLOZAPINE | Ki | = | 185.0 | nM | 6.73 |
| CHEMBL2022272 | — | Ki | = | 374.0 | nM | 6.43 |
| CHEMBL2022273 | — | Ki | = | 412.0 | nM | 6.38 |
| CHEMBL2022275 | — | Ki | = | 452.0 | nM | 6.34 |
| CHEMBL2022269 | — | Ki | = | 729.0 | nM | 6.14 |