Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL2026542

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to bovine tubulin after 1 hr by spectrofluorometric analysis
ChEMBL ↗
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

Synthesis and structure-activity relationship study of antimicrotubule agents phenylahistin derivatives with a didehydropiperazine-2,5-dione structure.
Yamazaki Y, Tanaka K, Nicholson B, Deyanat-Yazdi G, Potts B, Yoshida T, Oda A, Kitagawa T, Orikasa S, Kiso Y, Yasui H, Akamatsu M, Chinen T, Usui T, Shinozaki Y, Yakushiji F, Miller BR, Neuteboom S, Palladino M, Kanoh K, Lloyd GK, Hayashi Y.
J Med Chem (2012) 55 : 1056 -1071
PubMed 22185476 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 48 5.63 6.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2024544 — — 1 6.70
CHEMBL2024561 — — 1 6.21
CHEMBL2024542 — — 1 6.16
CHEMBL1096380 PLINABULIN 3.0 1 6.00
CHEMBL2024100 — — 1 5.96
CHEMBL2022198 — — 1 5.92
CHEMBL2024546 — — 1 5.80
CHEMBL2024550 — — 1 5.72
CHEMBL2024101 — — 1 5.70
CHEMBL2024545 — — 1 5.60
CHEMBL2024537 — — 1 5.58
CHEMBL2024538 — — 1 5.54
CHEMBL107 COLCHICINE 4.0 1 5.48
CHEMBL2022197 — — 1 5.35
CHEMBL2024099 — — 1 5.34
CHEMBL2024098 — — 1 5.31
CHEMBL2024097 — — 1 5.13
CHEMBL2024540 — — 1 5.10
CHEMBL2024539 — — 1 5.05
CHEMBL2024543 — — 1 4.93
CHEMBL2022195 — — 1 -
CHEMBL67 COMBRETASTATIN A4 -1.0 1 -
CHEMBL2022208 — — 1 -
CHEMBL2022207 — — 1 -
CHEMBL2022206 — — 1 -
CHEMBL2022205 — — 1 -
CHEMBL2022204 — — 1 -
CHEMBL2022203 — — 1 -
CHEMBL2022202 — — 1 -
CHEMBL2022201 — — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2024544 — Kd = 200.0 nM 6.70
CHEMBL2024561 — Kd = 620.0 nM 6.21
CHEMBL2024542 — Kd = 700.0 nM 6.16
CHEMBL1096380 PLINABULIN Kd = 1000.0 nM 6.00
CHEMBL2024100 — Kd = 1100.0 nM 5.96
CHEMBL2022198 — Kd = 1200.0 nM 5.92
CHEMBL2024546 — Kd = 1600.0 nM 5.80
CHEMBL2024550 — Kd = 1900.0 nM 5.72
CHEMBL2024101 — Kd = 2000.0 nM 5.70
CHEMBL2024545 — Kd = 2500.0 nM 5.60
CHEMBL2024537 — Kd = 2600.0 nM 5.58
CHEMBL2024538 — Kd = 2900.0 nM 5.54
CHEMBL107 COLCHICINE Kd = 3300.0 nM 5.48
CHEMBL2022197 — Kd = 4500.0 nM 5.35
CHEMBL2024099 — Kd = 4600.0 nM 5.34
CHEMBL2024098 — Kd = 4900.0 nM 5.31
CHEMBL2024097 — Kd = 7400.0 nM 5.13
CHEMBL2024540 — Kd = 8000.0 nM 5.10
CHEMBL2024539 — Kd = 8900.0 nM 5.05
CHEMBL2024543 — Kd = 11800.0 nM 4.93
CHEMBL2024549 — Kd - — -
CHEMBL2024547 — Kd - — -
CHEMBL2024551 — Kd - — -
CHEMBL2024552 — Kd - — -
CHEMBL2024553 — Kd - — -
CHEMBL2024554 — Kd - — -
CHEMBL2024555 — Kd - — -
CHEMBL2024556 — Kd - — -
CHEMBL2024557 — Kd - — -
CHEMBL2024558 — Kd - — -
CHEMBL2024559 — Kd - — -
CHEMBL2024560 — Kd - — -
CHEMBL2022194 — Kd - — -
CHEMBL2024548 — Kd - — -
CHEMBL2022196 — Kd - — -
CHEMBL2024541 — Kd - — -
CHEMBL2022199 — Kd - — -
CHEMBL2022200 — Kd - — -
CHEMBL2022201 — Kd - — -
CHEMBL2022202 — Kd - — -
CHEMBL2022203 — Kd - — -
CHEMBL2022204 — Kd - — -
CHEMBL2022205 — Kd - — -
CHEMBL2022206 — Kd - — -
CHEMBL2022207 — Kd - — -
CHEMBL2022208 — Kd - — -
CHEMBL67 COMBRETASTATIN A4 Kd - — -
CHEMBL2022195 — Kd - — -