Assay Detail
Binding
CHEMBL2026545
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine brain tubulin polymerization by thermostatic spectrophotometer
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationship study of antimicrotubule agents phenylahistin derivatives with a didehydropiperazine-2,5-dione structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.03 | 6.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2024544 | — | — | 1 | 6.29 |
| CHEMBL2022198 | — | — | 1 | 6.26 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 6.26 |
| CHEMBL2024561 | — | — | 1 | 6.12 |
| CHEMBL1096380 | PLINABULIN | 3.0 | 1 | 5.88 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2024544 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL2022198 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL2024561 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL1096380 | PLINABULIN | IC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL107 | COLCHICINE | IC50 | = | 4120.0 | nM | 5.38 |