Assay Detail
Binding
CHEMBL2026610
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mitochondrial MAO-A in rat liver homogenates using [14C]-(5-hydroxy-triptamine) as substrate preincubated for 30 mins by liquid scintillation counting
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Amine oxidase [flavin-containing] A (CHEMBL3358) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.72 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2022927 | — | — | 1 | 9.10 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.40 |
| CHEMBL2022924 | — | — | 1 | 7.00 |
| CHEMBL2022925 | — | — | 1 | 6.82 |
| CHEMBL2022928 | — | — | 1 | 6.82 |
| CHEMBL2022926 | — | — | 1 | 6.72 |
| CHEMBL2021938 | — | — | 1 | 5.90 |
| CHEMBL2022923 | — | — | 1 | 4.00 |
| CHEMBL2022929 | — | — | 1 | - |
| CHEMBL2022930 | — | — | 1 | - |
| CHEMBL2022931 | — | — | 1 | - |
| CHEMBL2022932 | — | — | 1 | - |
| CHEMBL2022933 | — | — | 1 | - |
| CHEMBL2022934 | — | — | 1 | - |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2022927 | — | IC50 | = | 0.79 | nM | 9.10 |
| CHEMBL95 | TACRINE | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2022924 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2022925 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2022928 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2022926 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL2021938 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL2022923 | — | IC50 | = | 99260.0 | nM | 4.00 |
| CHEMBL2022929 | — | IC50 | = | 240500.0 | nM | - |
| CHEMBL2022930 | — | IC50 | = | 1050000.0 | nM | - |
| CHEMBL2022931 | — | IC50 | = | 494700.0 | nM | - |
| CHEMBL2022932 | — | IC50 | = | 1001000.0 | nM | - |
| CHEMBL2022933 | — | IC50 | = | 618300.0 | nM | - |
| CHEMBL2022934 | — | IC50 | = | 330200.0 | nM | - |
| CHEMBL502 | DONEPEZIL | IC50 | = | 850000.0 | nM | - |