Assay Detail
ADMET
CHEMBL2027127
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Cytotoxicity against HUVEC after 48 hrs using resazurin by microplate fluorometer analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HUVEC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationship study of antimicrotubule agents phenylahistin derivatives with a didehydropiperazine-2,5-dione structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.52 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2024561 | — | — | 1 | 9.30 |
| CHEMBL2024544 | — | — | 1 | 8.82 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.62 |
| CHEMBL1096380 | PLINABULIN | 3.0 | 1 | 7.96 |
| CHEMBL2022198 | — | — | 1 | 7.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2024561 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL2024544 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL1096380 | PLINABULIN | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2022198 | — | IC50 | = | 13.0 | nM | 7.89 |