Assay Detail
Binding
CHEMBL2027645
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant renin using H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn-OH as substrate assessed as formation of angiotensin1 product after 2 hrs by competive radioimmunoassay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 9.27 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2023123 | — | — | 1 | 9.82 |
| CHEMBL2024249 | — | — | 1 | 9.57 |
| CHEMBL1276678 | VTP-27999 | 1.0 | 1 | 9.52 |
| CHEMBL2024248 | — | — | 1 | 9.38 |
| CHEMBL1639 | ALISKIREN | 4.0 | 1 | 9.28 |
| CHEMBL2023124 | — | — | 1 | 8.77 |
| CHEMBL2023122 | — | — | 1 | 8.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2023123 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL2024249 | — | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL1276678 | VTP-27999 | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL2024248 | — | IC50 | = | 0.42 | nM | 9.38 |
| CHEMBL1639 | ALISKIREN | IC50 | = | 0.53 | nM | 9.28 |
| CHEMBL2023124 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL2023122 | — | IC50 | = | 2.7 | nM | 8.57 |