Assay Detail
Binding
CHEMBL2027646
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of renin in human plasma assessed as formation of angiotensin1 product after 90 mins by competitive radioimmunoassay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.55 | 9.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2024248 | — | — | 1 | 9.32 |
| CHEMBL1639 | ALISKIREN | 4.0 | 1 | 9.19 |
| CHEMBL591578 | — | — | 1 | 9.09 |
| CHEMBL2023123 | — | — | 1 | 8.97 |
| CHEMBL1276678 | VTP-27999 | 1.0 | 1 | 8.96 |
| CHEMBL2023122 | — | — | 1 | 8.35 |
| CHEMBL484897 | — | — | 1 | 8.03 |
| CHEMBL2023124 | — | — | 1 | 7.88 |
| CHEMBL2024249 | — | — | 1 | 7.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2024248 | — | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL1639 | ALISKIREN | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL591578 | — | IC50 | = | 0.82 | nM | 9.09 |
| CHEMBL2023123 | — | IC50 | = | 1.06 | nM | 8.97 |
| CHEMBL1276678 | VTP-27999 | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL2023122 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL484897 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL2023124 | — | IC50 | = | 13.1 | nM | 7.88 |
| CHEMBL2024249 | — | IC50 | = | 69.0 | nM | 7.16 |