Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL2028076

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
MMV: Inhibition of Leishmania infantum (MHOM/MA/BE/67) in vitro.
ChEMBL ↗
400
Total Activities
400
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Leishmania infantum
Confidence 1 — Organism
Curated By Autocuration

Target

Leishmania infantum (CHEMBL612848) ↗
Type ORGANISM
Organism Leishmania infantum

Publication

Malaria Box
Simon Macdonald, Paul Willis, Paul Kowalczyk, Thomas Spangenberg, Jeremy Burrows and Tim Wells. Medicines for Malaria Venture (MMV), PO Box 1826, 20, rte de Pré-Bois, 1215 Geneva 15, Switzerland and SCYNEXIS Inc. P.O. Box 12878 Research Triangle Park, North Carolina 27709-2878 USA

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 400 5.12 6.47

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL591637 — — 1 6.47
CHEMBL597248 — — 1 6.15
CHEMBL494669 — — 1 6.08
CHEMBL584015 — — 1 6.07
CHEMBL537087 — — 1 6.00
CHEMBL598279 — — 1 6.00
CHEMBL582767 — — 1 6.00
CHEMBL586033 — — 1 6.00
CHEMBL124006 — — 1 5.99
CHEMBL581225 — — 1 5.99
CHEMBL534319 — — 1 5.99
CHEMBL1437888 — — 1 5.99
CHEMBL602946 — — 1 5.97
CHEMBL580516 — — 1 5.92
CHEMBL2028050 — — 1 5.92
CHEMBL585622 — — 1 5.92
CHEMBL591183 — — 1 5.92
CHEMBL601041 — — 1 5.80
CHEMBL592123 — — 1 5.80
CHEMBL530308 — — 1 5.80
CHEMBL588481 — — 1 5.80
CHEMBL591362 — — 1 5.80
CHEMBL602413 — — 1 5.60
CHEMBL533855 — — 1 5.60
CHEMBL590933 — — 1 5.59
CHEMBL579105 — — 1 5.59
CHEMBL527730 — — 1 5.53
CHEMBL534283 — — 1 5.53
CHEMBL581860 — — 1 5.52
CHEMBL588855 — — 1 5.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL591637 — IC50 = 336.48 nM 6.47
CHEMBL597248 — IC50 = 707.11 nM 6.15
CHEMBL494669 — IC50 = 840.9 nM 6.08
CHEMBL584015 — IC50 = 846.45 nM 6.07
CHEMBL537087 — IC50 = 1000.0 nM 6.00
CHEMBL582767 — IC50 = 1000.0 nM 6.00
CHEMBL586033 — IC50 = 1000.0 nM 6.00
CHEMBL598279 — IC50 = 1007.03 nM 6.00
CHEMBL1437888 — IC50 = 1014.25 nM 5.99
CHEMBL534319 — IC50 = 1014.25 nM 5.99
CHEMBL124006 — IC50 = 1014.25 nM 5.99
CHEMBL581225 — IC50 = 1014.25 nM 5.99
CHEMBL602946 — IC50 = 1080.06 nM 5.97
CHEMBL580516 — IC50 = 1189.21 nM 5.92
CHEMBL591183 — IC50 = 1189.21 nM 5.92
CHEMBL585622 — IC50 = 1189.21 nM 5.92
CHEMBL2028050 — IC50 = 1189.21 nM 5.92
CHEMBL601041 — IC50 = 1587.4 nM 5.80
CHEMBL530308 — IC50 = 1587.4 nM 5.80
CHEMBL588481 — IC50 = 1587.4 nM 5.80
CHEMBL591362 — IC50 = 1587.4 nM 5.80
CHEMBL592123 — IC50 = 1587.4 nM 5.80
CHEMBL533855 — IC50 = 2519.84 nM 5.60
CHEMBL602413 — IC50 = 2519.84 nM 5.60
CHEMBL579105 — IC50 = 2573.33 nM 5.59
CHEMBL590933 — IC50 = 2540.0 nM 5.59
CHEMBL534283 — IC50 = 2971.99 nM 5.53
CHEMBL527730 — IC50 = 2971.99 nM 5.53
CHEMBL581860 — IC50 = 3006.81 nM 5.52
CHEMBL605751 — IC50 = 3006.81 nM 5.52
CHEMBL602580 — IC50 = 3006.81 nM 5.52
CHEMBL586031 — IC50 = 3006.81 nM 5.52
CHEMBL588855 — IC50 = 3006.81 nM 5.52
CHEMBL589723 — IC50 = 3063.93 nM 5.51
CHEMBL602234 — IC50 = 3408.72 nM 5.47
CHEMBL602312 — IC50 = 4000.0 nM 5.40
CHEMBL532141 — IC50 = 4000.0 nM 5.40
CHEMBL587892 — IC50 = 4000.0 nM 5.40
CHEMBL578030 — IC50 = 4000.0 nM 5.40
CHEMBL525106 — IC50 = 4000.0 nM 5.40
CHEMBL584235 — IC50 = 4000.0 nM 5.40
CHEMBL547825 — IC50 = 4000.0 nM 5.40
CHEMBL600374 — IC50 = 4000.0 nM 5.40
CHEMBL1616787 — IC50 = 4056.99 nM 5.39
CHEMBL601122 — IC50 = 4056.99 nM 5.39
CHEMBL537778 — IC50 = 4056.99 nM 5.39
CHEMBL596852 — IC50 = 4056.99 nM 5.39
CHEMBL588501 — IC50 = 4056.99 nM 5.39
CHEMBL2028043 — IC50 = 4056.99 nM 5.39
CHEMBL600132 — IC50 = 4028.1 nM 5.39