Assay Detail
Binding
CHEMBL2032459
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of RON by HTRF assay
3
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Macrophage-stimulating protein receptor (CHEMBL2689) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-based design of novel class II c-Met inhibitors: 2. SAR and kinase selectivity profiles of the pyrazolone series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.00 | 8.00 |
| Ki | 1 | 9.00 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2031893 | — | — | 2 | 9.00 |
| CHEMBL460472 | — | — | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2031893 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL460472 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2031893 | — | IC50 | = | 10.0 | nM | 8.00 |