Assay Detail

CHEMBL2032499

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Functional

Induction of apoptosis in human Caco2 cells assessed as increase in caspase 3/7 activity

ChEMBL ↗

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Target

Caco-2 (CHEMBL614058) ↗

Open DB target context

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Caco-2 (CHEMBL614058) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Caco-2

CHEMBL614058

Anchored from Assay target.

Protein identity Caco-2

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	Caco-2
Confidence	1 — Organism
Curated By	Autocuration

Target

Caco-2 (CHEMBL614058) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Discovery of XL413, a potent and selective CDC7 inhibitor.

Koltun ES, Tsuhako AL, Brown DS, Aay N, Arcalas A, Chan V, Du H, Engst S, Ferguson K, Franzini M, Galan A, Holst CR, Huang P, Kane B, Kim MH, Li J, Markby D, Mohan M, Noson K, Plonowski A, Richards SJ, Robertson S, Shaw K, Stott G, Stout TJ, Young J, Yu P, Zaharia CA, Zhang W, Zhou P, Nuss JM, Xu W, Kearney PC.
Bioorg Med Chem Lett (2012) 22 : 3727 -3731
PubMed 22560567 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	5.64	5.64

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL2030402	—	—	1	5.64

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL2030402	—	EC50	=	2288.0	nM	5.64