Assay Detail
Binding
CHEMBL2032664
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Inhibition of human recombinant CDK5/p25 using [gamma 33P]ATP after 30 mins by scintillation counting
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 5/CDK5 activator 1 (CHEMBL1907600) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Synthesis, biological evaluation, and molecular modeling of natural and unnatural flavonoidal alkaloids, inhibitors of kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.40 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2029619 | — | — | 1 | 7.40 |
| CHEMBL2029615 | — | — | 1 | 7.30 |
| CHEMBL428690 | ALVOCIDIB | 3.0 | 1 | 7.22 |
| CHEMBL2029617 | — | — | 1 | 7.05 |
| CHEMBL2029622 | — | — | 1 | 6.57 |
| CHEMBL2029621 | — | — | 1 | 6.28 |
| CHEMBL2029618 | — | — | 1 | 6.24 |
| CHEMBL2029614 | — | — | 1 | 6.02 |
| CHEMBL2029620 | — | — | 1 | 5.96 |
| CHEMBL489967 | — | — | 1 | 5.77 |
| CHEMBL2029623 | — | — | 1 | 5.68 |
| CHEMBL523951 | — | — | 1 | 5.26 |
| CHEMBL2029616 | — | — | 1 | - |
| CHEMBL490159 | BUCHENAVIANINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2029619 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2029615 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL428690 | ALVOCIDIB | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL2029617 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL2029622 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL2029621 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL2029618 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL2029614 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL2029620 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL489967 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL2029623 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL523951 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL2029616 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL490159 | BUCHENAVIANINE | IC50 | > | 10000.0 | nM | - |