Assay Detail
Binding
CHEMBL2032665
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Inhibition of porcine brain GSK3alpha/beta using GS1 as substrate
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis, biological evaluation, and molecular modeling of natural and unnatural flavonoidal alkaloids, inhibitors of kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.73 | 6.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428690 | ALVOCIDIB | 3.0 | 1 | 6.44 |
| CHEMBL2029619 | — | — | 1 | 6.14 |
| CHEMBL2029617 | — | — | 1 | 5.89 |
| CHEMBL2029615 | — | — | 1 | 5.80 |
| CHEMBL2029618 | — | — | 1 | 5.58 |
| CHEMBL2029622 | — | — | 1 | 5.39 |
| CHEMBL489967 | — | — | 1 | 5.29 |
| CHEMBL2029621 | — | — | 1 | 5.28 |
| CHEMBL2029614 | — | — | 1 | - |
| CHEMBL523951 | — | — | 1 | - |
| CHEMBL2029616 | — | — | 1 | - |
| CHEMBL490159 | BUCHENAVIANINE | — | 1 | - |
| CHEMBL2029620 | — | — | 1 | - |
| CHEMBL2029623 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428690 | ALVOCIDIB | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL2029619 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL2029617 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL2029615 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL2029618 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL2029622 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL489967 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL2029621 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL2029614 | — | IC50 | >= | 10000.0 | nM | - |
| CHEMBL523951 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2029616 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL490159 | BUCHENAVIANINE | IC50 | > | 10000.0 | nM | - |
| CHEMBL2029620 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2029623 | — | IC50 | > | 10000.0 | nM | - |