Assay Detail
Binding
CHEMBL2032679
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of wild type human glucocerebrosidase using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 15 mins by Dixon and Line-Weaver Burk plot analysis at pH 5
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Rapid assembly of a library of lipophilic iminosugars via the thiol-ene reaction yields promising pharmacological chaperones for the treatment of Gaucher disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 8.34 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2029773 | — | — | 1 | 9.40 |
| CHEMBL2029772 | — | — | 1 | 8.74 |
| CHEMBL2029780 | — | — | 1 | 8.52 |
| CHEMBL2029778 | — | — | 1 | 8.40 |
| CHEMBL2029776 | — | — | 1 | 8.36 |
| CHEMBL2029777 | — | — | 1 | 8.22 |
| CHEMBL2029782 | — | — | 1 | 7.92 |
| CHEMBL2029771 | — | — | 1 | 7.75 |
| CHEMBL2029779 | — | — | 1 | 7.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2029773 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL2029772 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL2029780 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL2029778 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL2029776 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL2029777 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL2029782 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL2029771 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL2029779 | — | Ki | = | 19.0 | nM | 7.72 |