Assay Detail
Functional
CHEMBL2032763
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Antiproliferative activity against human SNU387 after 72 hrs by CellTiter Glo assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SNU-387 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Tubulin binding, protein-bound conformation in solution, and antimitotic cellular profiling of noscapine and its derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.67 | 8.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.37 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 7.70 |
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | 7.39 |
| CHEMBL376130 | — | — | 1 | 7.22 |
| CHEMBL364713 | NOSCAPINE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL90555 | VINCRISTINE | IC50 | = | 40.9 | nM | 7.39 |
| CHEMBL376130 | — | IC50 | = | 59.5 | nM | 7.22 |
| CHEMBL364713 | NOSCAPINE | IC50 | > | 1000.0 | nM | - |