Assay Detail
Functional
CHEMBL2032840
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at neuropeptide Y receptor Y2
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and SAR of selective small molecule neuropeptide Y Y2 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 43 | 6.50 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2030189 | — | — | 1 | 7.92 |
| CHEMBL2030155 | — | — | 1 | 7.72 |
| CHEMBL2030190 | — | — | 1 | 7.31 |
| CHEMBL2030192 | — | — | 1 | 7.23 |
| CHEMBL2030188 | — | — | 1 | 7.21 |
| CHEMBL2030185 | — | — | 1 | 7.17 |
| CHEMBL2030148 | — | — | 1 | 7.14 |
| CHEMBL2030154 | — | — | 1 | 7.11 |
| CHEMBL2030163 | — | — | 1 | 7.07 |
| CHEMBL2030183 | — | — | 1 | 7.05 |
| CHEMBL2030179 | — | — | 1 | 7.01 |
| CHEMBL2030157 | — | — | 1 | 6.93 |
| CHEMBL2030158 | — | — | 1 | 6.92 |
| CHEMBL2030156 | — | — | 1 | 6.87 |
| CHEMBL2030191 | — | — | 1 | 6.85 |
| CHEMBL2030146 | — | — | 1 | 6.75 |
| CHEMBL1543306 | — | — | 1 | 6.72 |
| CHEMBL2030152 | — | — | 1 | 6.69 |
| CHEMBL2030150 | — | — | 1 | 6.68 |
| CHEMBL2030193 | — | — | 1 | 6.66 |
| CHEMBL2030180 | — | — | 1 | 6.61 |
| CHEMBL2030153 | — | — | 1 | 6.52 |
| CHEMBL2030164 | — | — | 1 | 6.49 |
| CHEMBL2030175 | — | — | 1 | 6.43 |
| CHEMBL2030196 | — | — | 1 | 6.41 |
| CHEMBL1427860 | — | — | 1 | 6.36 |
| CHEMBL2030176 | — | — | 1 | 6.32 |
| CHEMBL2030147 | — | — | 1 | 6.21 |
| CHEMBL2030145 | — | — | 1 | 6.11 |
| CHEMBL2030165 | — | — | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2030189 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2030155 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2030190 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL2030192 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL2030188 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL2030185 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL2030148 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL2030154 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL2030163 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL2030183 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL2030179 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL2030157 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL2030158 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL2030156 | — | IC50 | = | 136.0 | nM | 6.87 |
| CHEMBL2030191 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL2030146 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL1543306 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL2030152 | — | IC50 | = | 206.0 | nM | 6.69 |
| CHEMBL2030150 | — | IC50 | = | 207.0 | nM | 6.68 |
| CHEMBL2030193 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL2030180 | — | IC50 | = | 248.0 | nM | 6.61 |
| CHEMBL2030153 | — | IC50 | = | 301.0 | nM | 6.52 |
| CHEMBL2030164 | — | IC50 | = | 323.0 | nM | 6.49 |
| CHEMBL2030175 | — | IC50 | = | 371.0 | nM | 6.43 |
| CHEMBL2030196 | — | IC50 | = | 394.0 | nM | 6.41 |
| CHEMBL1427860 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL2030176 | — | IC50 | = | 483.0 | nM | 6.32 |
| CHEMBL2030147 | — | IC50 | = | 612.0 | nM | 6.21 |
| CHEMBL2030145 | — | IC50 | = | 777.0 | nM | 6.11 |
| CHEMBL2030165 | — | IC50 | = | 899.0 | nM | 6.05 |
| CHEMBL2029961 | — | IC50 | = | 1047.0 | nM | 5.98 |
| CHEMBL1370218 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1404069 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2029356 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2030169 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL2030151 | — | IC50 | = | 1419.0 | nM | 5.85 |
| CHEMBL2030187 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL2029960 | — | IC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL2030186 | — | IC50 | = | 2680.0 | nM | 5.57 |
| CHEMBL2030182 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL1608982 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL2030172 | — | IC50 | = | 6760.0 | nM | 5.17 |
| CHEMBL2030171 | — | IC50 | > | 10000.0 | nM | - |