Assay Detail
Binding
CHEMBL2033108
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Inhibition of Plasmodium falciparum recombinant NDH2 expressed in Escherichia coli F571 using decyclubiquinone as substrate at 1 min by spectrophotometry
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Identification, design and biological evaluation of bisaryl quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 7.19 | 8.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2030038 | — | — | 1 | 8.21 |
| CHEMBL2030027 | — | — | 1 | 8.00 |
| CHEMBL2030035 | — | — | 1 | 7.92 |
| CHEMBL2030060 | — | — | 1 | 7.87 |
| CHEMBL2030016 | — | — | 1 | 7.80 |
| CHEMBL2030010 | — | — | 1 | 7.80 |
| CHEMBL2030044 | — | — | 1 | 7.72 |
| CHEMBL2030009 | — | — | 1 | 7.56 |
| CHEMBL2030036 | — | — | 1 | 7.51 |
| CHEMBL2030028 | — | — | 1 | 7.49 |
| CHEMBL2030029 | — | — | 1 | 7.44 |
| CHEMBL2030005 | — | — | 1 | 7.32 |
| CHEMBL2030011 | — | — | 1 | 7.30 |
| CHEMBL2030004 | — | — | 1 | 7.28 |
| CHEMBL2030058 | — | — | 1 | 7.26 |
| CHEMBL2030061 | — | — | 1 | 7.15 |
| CHEMBL2029824 | — | — | 1 | 7.05 |
| CHEMBL2030034 | — | — | 1 | 7.01 |
| CHEMBL2030062 | — | — | 1 | 6.97 |
| CHEMBL2030013 | — | — | 1 | 6.95 |
| CHEMBL2030047 | — | — | 1 | 6.86 |
| CHEMBL2030040 | — | — | 1 | 6.76 |
| CHEMBL2030049 | — | — | 1 | 6.72 |
| CHEMBL2030025 | — | — | 1 | 6.71 |
| CHEMBL2030007 | — | — | 1 | 6.60 |
| CHEMBL2030051 | — | — | 1 | 6.57 |
| CHEMBL2030286 | — | — | 1 | 6.55 |
| CHEMBL2030048 | — | — | 1 | 6.31 |
| CHEMBL2030008 | — | — | 1 | 5.78 |
| CHEMBL2029355 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2030038 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL2030027 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL2030035 | — | IC50 | = | 12.1 | nM | 7.92 |
| CHEMBL2030060 | — | IC50 | = | 13.5 | nM | 7.87 |
| CHEMBL2030016 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL2030010 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL2030044 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2030009 | — | IC50 | = | 27.4 | nM | 7.56 |
| CHEMBL2030036 | — | IC50 | = | 30.9 | nM | 7.51 |
| CHEMBL2030028 | — | IC50 | = | 32.2 | nM | 7.49 |
| CHEMBL2030029 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL2030005 | — | IC50 | = | 47.9 | nM | 7.32 |
| CHEMBL2030011 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2030004 | — | IC50 | = | 52.9 | nM | 7.28 |
| CHEMBL2030058 | — | IC50 | = | 55.2 | nM | 7.26 |
| CHEMBL2030061 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL2029824 | — | IC50 | = | 88.5 | nM | 7.05 |
| CHEMBL2030034 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL2030062 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL2030013 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL2030047 | — | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL2030040 | — | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL2030049 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL2030025 | — | IC50 | = | 196.0 | nM | 6.71 |
| CHEMBL2030007 | — | IC50 | = | 253.0 | nM | 6.60 |
| CHEMBL2030051 | — | IC50 | = | 268.0 | nM | 6.57 |
| CHEMBL2030286 | — | IC50 | = | 279.0 | nM | 6.55 |
| CHEMBL2030048 | — | IC50 | = | 492.0 | nM | 6.31 |
| CHEMBL2030008 | — | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL2029355 | — | IC50 | > | 56000.0 | nM | - |
| CHEMBL2030012 | — | IC50 | < | 1.0 | nM | - |