Assay Detail
Binding
CHEMBL2033109
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Inhibition of Plasmodium falciparum cytochrome b-c1 complex using decylubiquinol as substrate by spectrophotometry
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Identification, design and biological evaluation of bisaryl quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.91 | 7.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2030038 | — | — | 1 | 7.86 |
| CHEMBL2030012 | — | — | 1 | 7.59 |
| CHEMBL2030010 | — | — | 1 | 7.43 |
| CHEMBL2030011 | — | — | 1 | 6.66 |
| CHEMBL2030016 | — | — | 1 | 5.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2030038 | — | IC50 | = | 13.9 | nM | 7.86 |
| CHEMBL2030012 | — | IC50 | = | 25.5 | nM | 7.59 |
| CHEMBL2030010 | — | IC50 | = | 37.5 | nM | 7.43 |
| CHEMBL2030011 | — | IC50 | = | 219.0 | nM | 6.66 |
| CHEMBL2030016 | — | IC50 | = | 9800.0 | nM | 5.01 |