Assay Detail
Functional
CHEMBL2033110
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Antimalarial activity against atoquinone-resistant Plasmodium falciparum TM90C2B
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification, design and biological evaluation of bisaryl quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 6.55 | 8.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2030055 | — | — | 1 | 8.17 |
| CHEMBL2030023 | — | — | 1 | 7.51 |
| CHEMBL2030011 | — | — | 1 | 7.19 |
| CHEMBL2030052 | — | — | 1 | 7.04 |
| CHEMBL2030027 | — | — | 1 | 7.04 |
| CHEMBL2030024 | — | — | 1 | 7.03 |
| CHEMBL2030010 | — | — | 1 | 6.91 |
| CHEMBL2030016 | — | — | 1 | 6.75 |
| CHEMBL2030035 | — | — | 1 | 6.72 |
| CHEMBL2030036 | — | — | 1 | 6.68 |
| CHEMBL2030058 | — | — | 1 | 6.66 |
| CHEMBL2030056 | — | — | 1 | 6.65 |
| CHEMBL2030038 | — | — | 1 | 6.60 |
| CHEMBL2030028 | — | — | 1 | 6.56 |
| CHEMBL2030012 | — | — | 1 | 6.56 |
| CHEMBL2030047 | — | — | 1 | 6.48 |
| CHEMBL2030053 | — | — | 1 | 6.48 |
| CHEMBL2030061 | — | — | 1 | 6.39 |
| CHEMBL2030057 | — | — | 1 | 6.39 |
| CHEMBL2030009 | — | — | 1 | 6.38 |
| CHEMBL2030025 | — | — | 1 | 6.26 |
| CHEMBL2030062 | — | — | 1 | 6.25 |
| CHEMBL2030013 | — | — | 1 | 6.24 |
| CHEMBL2030039 | — | — | 1 | 6.20 |
| CHEMBL2030060 | — | — | 1 | 6.17 |
| CHEMBL2030029 | — | — | 1 | 6.10 |
| CHEMBL2030051 | — | — | 1 | 5.85 |
| CHEMBL2030034 | — | — | 1 | 5.73 |
| CHEMBL1450 | ATOVAQUONE | 4.0 | 1 | 4.92 |
| CHEMBL2030059 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2030055 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL2030023 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL2030011 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL2030052 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL2030027 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL2030024 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL2030010 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL2030016 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL2030035 | — | IC50 | = | 191.0 | nM | 6.72 |
| CHEMBL2030036 | — | IC50 | = | 207.0 | nM | 6.68 |
| CHEMBL2030058 | — | IC50 | = | 217.0 | nM | 6.66 |
| CHEMBL2030056 | — | IC50 | = | 224.0 | nM | 6.65 |
| CHEMBL2030038 | — | IC50 | = | 251.0 | nM | 6.60 |
| CHEMBL2030028 | — | IC50 | = | 274.0 | nM | 6.56 |
| CHEMBL2030012 | — | IC50 | = | 273.0 | nM | 6.56 |
| CHEMBL2030047 | — | IC50 | = | 328.0 | nM | 6.48 |
| CHEMBL2030053 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL2030061 | — | IC50 | = | 403.0 | nM | 6.39 |
| CHEMBL2030057 | — | IC50 | = | 406.0 | nM | 6.39 |
| CHEMBL2030009 | — | IC50 | = | 416.0 | nM | 6.38 |
| CHEMBL2030025 | — | IC50 | = | 552.0 | nM | 6.26 |
| CHEMBL2030062 | — | IC50 | = | 566.0 | nM | 6.25 |
| CHEMBL2030013 | — | IC50 | = | 577.0 | nM | 6.24 |
| CHEMBL2030039 | — | IC50 | = | 626.0 | nM | 6.20 |
| CHEMBL2030060 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL2030029 | — | IC50 | = | 797.0 | nM | 6.10 |
| CHEMBL2030051 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL2030034 | — | IC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL1450 | ATOVAQUONE | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL2030059 | — | IC50 | > | 1000.0 | nM | - |