Assay Detail
Functional
CHEMBL2033111
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Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification, design and biological evaluation of bisaryl quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.66 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2030058 | — | — | 1 | 8.10 |
| CHEMBL2030021 | — | — | 1 | 7.89 |
| CHEMBL2030016 | — | — | 1 | 7.77 |
| CHEMBL2030047 | — | — | 1 | 7.66 |
| CHEMBL2030010 | — | — | 1 | 7.58 |
| CHEMBL2030049 | — | — | 1 | 7.47 |
| CHEMBL2030038 | — | — | 1 | 7.44 |
| CHEMBL2030048 | — | — | 1 | 7.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2030058 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2030021 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2030016 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2030047 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL2030010 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL2030049 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL2030038 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL2030048 | — | IC50 | = | 42.0 | nM | 7.38 |