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Assay Detail

CHEMBL2033120

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Functional
Antimalarial activity against blood stage forms of Plasmodium falciparum 3D7 infected in human erythrocytes
ChEMBL ↗
62
Total Activities
62
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364) ↗
Type ORGANISM
Organism Plasmodium falciparum

Publication

Identification, design and biological evaluation of heterocyclic quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).
Leung SC, Gibbons P, Amewu R, Nixon GL, Pidathala C, Hong WD, Pacorel B, Berry NG, Sharma R, Stocks PA, Srivastava A, Shone AE, Charoensutthivarakul S, Taylor L, Berger O, Mbekeani A, Hill A, Fisher NE, Warman AJ, Biagini GA, Ward SA, O'Neill PM.
J Med Chem (2012) 55 : 1844 -1857
PubMed 22364417 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 62 6.69 7.51

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2030016 — — 1 7.51
CHEMBL2030333 — — 1 7.50
CHEMBL2030327 — — 1 7.40
CHEMBL2030298 — — 1 7.27
CHEMBL2030291 — — 1 7.23
CHEMBL2030304 — — 1 7.12
CHEMBL2030325 — — 1 7.03
CHEMBL2030292 — — 1 7.02
CHEMBL2030324 — — 1 6.99
CHEMBL2030313 — — 1 6.99
CHEMBL2030321 — — 1 6.96
CHEMBL2030329 — — 1 6.87
CHEMBL2030322 — — 1 6.82
CHEMBL2030297 — — 1 6.79
CHEMBL2030317 — — 1 6.70
CHEMBL2030293 — — 1 6.67
CHEMBL2030296 — — 1 6.66
CHEMBL2030314 — — 1 6.66
CHEMBL2030328 — — 1 6.55
CHEMBL2030316 — — 1 6.55
CHEMBL2030309 — — 1 6.54
CHEMBL2030300 — — 1 6.53
CHEMBL2030330 — — 1 6.50
CHEMBL2030310 — — 1 6.46
CHEMBL2030295 — — 1 6.46
CHEMBL2030305 — — 1 6.43
CHEMBL2030326 — — 1 6.43
CHEMBL2030311 — — 1 6.41
CHEMBL2030312 — — 1 6.41
CHEMBL2030294 — — 1 6.33

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2030016 — IC50 = 31.0 nM 7.51
CHEMBL2030333 — IC50 = 32.0 nM 7.50
CHEMBL2030327 — IC50 = 40.0 nM 7.40
CHEMBL2030298 — IC50 = 54.0 nM 7.27
CHEMBL2030291 — IC50 = 59.0 nM 7.23
CHEMBL2030304 — IC50 = 75.0 nM 7.12
CHEMBL2030325 — IC50 = 93.0 nM 7.03
CHEMBL2030292 — IC50 = 96.0 nM 7.02
CHEMBL2030324 — IC50 = 103.0 nM 6.99
CHEMBL2030313 — IC50 = 102.0 nM 6.99
CHEMBL2030321 — IC50 = 109.0 nM 6.96
CHEMBL2030329 — IC50 = 136.0 nM 6.87
CHEMBL2030322 — IC50 = 151.0 nM 6.82
CHEMBL2030297 — IC50 = 162.0 nM 6.79
CHEMBL2030317 — IC50 = 202.0 nM 6.70
CHEMBL2030293 — IC50 = 213.0 nM 6.67
CHEMBL2030296 — IC50 = 220.0 nM 6.66
CHEMBL2030314 — IC50 = 219.0 nM 6.66
CHEMBL2030328 — IC50 = 279.0 nM 6.55
CHEMBL2030316 — IC50 = 280.0 nM 6.55
CHEMBL2030309 — IC50 = 286.0 nM 6.54
CHEMBL2030300 — IC50 = 298.0 nM 6.53
CHEMBL2030330 — IC50 = 319.0 nM 6.50
CHEMBL2030310 — IC50 = 344.0 nM 6.46
CHEMBL2030295 — IC50 = 347.0 nM 6.46
CHEMBL2030305 — IC50 = 373.0 nM 6.43
CHEMBL2030326 — IC50 = 370.0 nM 6.43
CHEMBL2030311 — IC50 = 390.0 nM 6.41
CHEMBL2030312 — IC50 = 390.0 nM 6.41
CHEMBL2030294 — IC50 = 471.0 nM 6.33
CHEMBL2030335 — IC50 = 496.0 nM 6.30
CHEMBL2030315 — IC50 = 556.0 nM 6.25
CHEMBL2030495 — IC50 = 600.0 nM 6.22
CHEMBL2030496 — IC50 = 679.0 nM 6.17
CHEMBL2030290 — IC50 = 940.0 nM 6.03
CHEMBL2030323 — IC50 = 987.0 nM 6.01
CHEMBL2030339 — IC50 > 1000.0 nM -
CHEMBL2030340 — IC50 > 1000.0 nM -
CHEMBL2030341 — IC50 > 1000.0 nM -
CHEMBL2030489 — IC50 > 1000.0 nM -
CHEMBL2030490 — IC50 > 1000.0 nM -
CHEMBL2030491 — IC50 > 1000.0 nM -
CHEMBL2030492 — IC50 > 1000.0 nM -
CHEMBL2030493 — IC50 > 1000.0 nM -
CHEMBL2030494 — IC50 > 1000.0 nM -
CHEMBL2030289 — IC50 > 1000.0 nM -
CHEMBL2030302 — IC50 > 1000.0 nM -
CHEMBL2030301 — IC50 > 1000.0 nM -
CHEMBL2030299 — IC50 > 1000.0 nM -
CHEMBL2030338 — IC50 > 1000.0 nM -