Assay Detail
Binding
CHEMBL2033121
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Inhibition of Plasmodium falciparum recombinant NDH2 expressed in Escherichia coli F571 using decyclubiquinone as substrate at 1 min by spectrophotometry
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Identification, design and biological evaluation of heterocyclic quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.32 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2030309 | — | — | 1 | 8.59 |
| CHEMBL2030304 | — | — | 1 | 8.38 |
| CHEMBL2030292 | — | — | 1 | 8.09 |
| CHEMBL2030313 | — | — | 1 | 7.86 |
| CHEMBL2030298 | — | — | 1 | 7.82 |
| CHEMBL2030297 | — | — | 1 | 7.16 |
| CHEMBL2030314 | — | — | 1 | 7.05 |
| CHEMBL2030327 | — | — | 1 | 6.96 |
| CHEMBL2030322 | — | — | 1 | 6.88 |
| CHEMBL2030321 | — | — | 1 | 6.45 |
| CHEMBL2030324 | — | — | 1 | 6.39 |
| CHEMBL2030328 | — | — | 1 | 6.23 |
| CHEMBL2030291 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2030309 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL2030304 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL2030292 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL2030313 | — | IC50 | = | 13.9 | nM | 7.86 |
| CHEMBL2030298 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2030297 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL2030314 | — | IC50 | = | 88.6 | nM | 7.05 |
| CHEMBL2030327 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2030322 | — | IC50 | = | 131.0 | nM | 6.88 |
| CHEMBL2030321 | — | IC50 | = | 352.0 | nM | 6.45 |
| CHEMBL2030324 | — | IC50 | = | 407.0 | nM | 6.39 |
| CHEMBL2030328 | — | IC50 | = | 588.0 | nM | 6.23 |
| CHEMBL2030291 | — | IC50 | < | 1.0 | nM | - |