Assay Detail
Binding
CHEMBL2033122
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Inhibition of Plasmodium falciparum cytochrome b-c1 complex using decylubiquinol as substrate by spectrophotometry
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Identification, design and biological evaluation of heterocyclic quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.60 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2030298 | — | — | 1 | 7.82 |
| CHEMBL2030304 | — | — | 1 | 7.57 |
| CHEMBL2030291 | — | — | 1 | 7.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2030298 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2030304 | — | IC50 | = | 26.8 | nM | 7.57 |
| CHEMBL2030291 | — | IC50 | = | 38.0 | nM | 7.42 |