Assay Detail
Functional
CHEMBL2033123
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Antimalarial activity against atoquinone-resistant Plasmodium falciparum TM90C2B containing cytochrome-b Y268S mutant
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification, design and biological evaluation of heterocyclic quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.23 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2030313 | — | — | 1 | 6.50 |
| CHEMBL2030291 | — | — | 1 | 6.49 |
| CHEMBL2030322 | — | — | 1 | 6.49 |
| CHEMBL2030298 | — | — | 1 | 6.46 |
| CHEMBL2030297 | — | — | 1 | 6.44 |
| CHEMBL2030321 | — | — | 1 | 6.42 |
| CHEMBL2030300 | — | — | 1 | 6.39 |
| CHEMBL2030296 | — | — | 1 | 5.94 |
| CHEMBL1450 | ATOVAQUONE | 4.0 | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2030313 | — | IC50 | = | 314.0 | nM | 6.50 |
| CHEMBL2030291 | — | IC50 | = | 326.0 | nM | 6.49 |
| CHEMBL2030322 | — | IC50 | = | 324.0 | nM | 6.49 |
| CHEMBL2030298 | — | IC50 | = | 344.0 | nM | 6.46 |
| CHEMBL2030297 | — | IC50 | = | 361.0 | nM | 6.44 |
| CHEMBL2030321 | — | IC50 | = | 381.0 | nM | 6.42 |
| CHEMBL2030300 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL2030296 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL1450 | ATOVAQUONE | IC50 | = | 12000.0 | nM | 4.92 |