Assay Detail
Functional
CHEMBL2033124
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Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification, design and biological evaluation of heterocyclic quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.86 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2030298 | — | — | 1 | 7.30 |
| CHEMBL2030327 | — | — | 1 | 7.30 |
| CHEMBL2030329 | — | — | 1 | 7.17 |
| CHEMBL2030304 | — | — | 1 | 7.16 |
| CHEMBL2030321 | — | — | 1 | 7.06 |
| CHEMBL2030322 | — | — | 1 | 6.92 |
| CHEMBL2030326 | — | — | 1 | 6.48 |
| CHEMBL2030333 | — | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2030298 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2030327 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2030329 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL2030304 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL2030321 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL2030322 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2030326 | — | IC50 | = | 329.0 | nM | 6.48 |
| CHEMBL2030333 | — | IC50 | = | 3073.0 | nM | 5.51 |