Assay Detail
Binding
CHEMBL2033178
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant CDK2/CycE using HHASPRK as substrate by ESI-MS analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 2/cyclin E1 (CHEMBL1907605) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Identification of binding specificity-determining features in protein families.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.16 | 9.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL306498 | ALOISINE | — | 1 | 9.28 |
| CHEMBL319467 | — | — | 1 | 8.98 |
| CHEMBL411491 | — | — | 1 | 6.97 |
| CHEMBL505177 | SCYTONEMIN | — | 1 | 6.43 |
| CHEMBL261641 | — | — | 1 | 6.31 |
| CHEMBL76904 | TYRPHOSTIN 23 | — | 1 | 6.21 |
| CHEMBL407391 | DIMETHYLADENINE | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL306498 | ALOISINE | Ki | = | 0.5248 | nM | 9.28 |
| CHEMBL319467 | — | Ki | = | 1.047 | nM | 8.98 |
| CHEMBL411491 | — | Ki | = | 107.15 | nM | 6.97 |
| CHEMBL505177 | SCYTONEMIN | Ki | = | 371.54 | nM | 6.43 |
| CHEMBL261641 | — | Ki | = | 489.78 | nM | 6.31 |
| CHEMBL76904 | TYRPHOSTIN 23 | Ki | = | 616.6 | nM | 6.21 |
| CHEMBL407391 | DIMETHYLADENINE | Ki | = | 1096.48 | nM | 5.96 |