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Assay Detail

CHEMBL2033181

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of beta-lactamase CTX-M using nitrocefin as substrate
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Structure-based design of potent and ligand-efficient inhibitors of CTX-M class A β-lactamase.
Nichols DA, Jaishankar P, Larson W, Smith E, Liu G, Beyrouthy R, Bonnet R, Renslo AR, Chen Y.
J Med Chem (2012) 55 : 2163 -2172
PubMed 22296601 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 24 5.43 7.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2031559 1 7.05
CHEMBL2031560 1 6.24
CHEMBL2031561 1 6.20
CHEMBL2031562 1 6.00
CHEMBL2031558 1 5.96
CHEMBL2031556 1 5.89
CHEMBL2031557 1 5.72
CHEMBL2031551 1 5.62
CHEMBL2031563 1 5.57
CHEMBL2031545 1 5.52
CHEMBL2031546 1 5.51
CHEMBL2031549 1 5.42
CHEMBL2031544 1 5.35
CHEMBL2031543 1 5.21
CHEMBL2031555 1 5.18
CHEMBL2031550 1 5.16
CHEMBL2031554 1 5.14
CHEMBL2031552 1 5.01
CHEMBL2031548 1 4.99
CHEMBL2031547 1 4.77
CHEMBL1213447 1 4.68
CHEMBL2031564 1 4.47
CHEMBL2031553 1 4.12
CHEMBL331628 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2031559 Ki = 89.0 nM 7.05
CHEMBL2031560 Ki = 570.0 nM 6.24
CHEMBL2031561 Ki = 630.0 nM 6.20
CHEMBL2031562 Ki = 1000.0 nM 6.00
CHEMBL2031558 Ki = 1100.0 nM 5.96
CHEMBL2031556 Ki = 1300.0 nM 5.89
CHEMBL2031557 Ki = 1900.0 nM 5.72
CHEMBL2031551 Ki = 2400.0 nM 5.62
CHEMBL2031563 Ki = 2700.0 nM 5.57
CHEMBL2031545 Ki = 3000.0 nM 5.52
CHEMBL2031546 Ki = 3100.0 nM 5.51
CHEMBL2031549 Ki = 3800.0 nM 5.42
CHEMBL2031544 Ki = 4500.0 nM 5.35
CHEMBL2031543 Ki = 6200.0 nM 5.21
CHEMBL2031555 Ki = 6600.0 nM 5.18
CHEMBL2031550 Ki = 6900.0 nM 5.16
CHEMBL2031554 Ki = 7200.0 nM 5.14
CHEMBL2031552 Ki = 9700.0 nM 5.01
CHEMBL2031548 Ki = 10200.0 nM 4.99
CHEMBL2031547 Ki = 17100.0 nM 4.77
CHEMBL1213447 Ki = 21000.0 nM 4.68
CHEMBL2031564 Ki = 34100.0 nM 4.47
CHEMBL2031553 Ki = 76000.0 nM 4.12
CHEMBL331628 Ki - -